Up-regulation of hnRNP A1, Ezrin, tubulin β-2C and Annexin A1 in sentinel lymph nodes of colorectal cancer
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Annexin A1 and the regulation of innate and adaptive immunity
Inflammation is the body's way of defending itself against noxious stimuli and pathogens. Under normal circumstances, the body is able to eliminate the insult and subsequently promote the resolution of inflammation and the repair of damaged tissues. The concept of homeostasis is one that not only requires a fine balance between both pro-inflammatory mediators and pro-resolving/anti-inflammatory...
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lymph node status remains an important prognostic indicator for survival in breast cancer. sentinel lymph node biopsy has become the standard method of assessment of clinically node negative breast cancers. economic implications as well as patient related factors have lead to the development a number of intra-operative techniques. review of the emerging trends in the last 4 years show that alth...
متن کاملRegulation of γ fibrinogen chain expression by hnRNP A1
Earlier studies showed that HepG2 cells stably transfected with any one fibrinogen chain cDNA enhance the expression of the other two fibrinogen chains. In this report, a regulatory element “TGCTCTC” in the γ fibrinogen promoter region, -322 to -316, is identified which is involved in increased expression of γ chain in HepG2 cells that are transfected with Bβ fibrinogen cDNA. By electrophoretic...
متن کاملClinical Significance of Annexin A1 Expression in Breast Cancer
PURPOSE The expression of Annexin A1 (ANXA1) is known to be reduced in human breast cancer; however, the role of ANXA1 expression in the development of breast cancer remains unclear. In this study, we determined the relationship between the expression features of ANXA1 and the prognostic factors of breast cancer. METHODS Human breast tissues were obtained from patients specimens who had under...
متن کاملAnnexin A1 attenuates EMT and metastatic potential in breast cancer
Metastasis is the major cause of carcinoma-induced death, but mechanisms involved are poorly understood. Metastasis crucially involves epithelial-to-mesenchymal transition (EMT), causing loss of epithelial polarity. Here we identify Annexin A1 (AnxA1), a protein with important functions in intracellular vesicle trafficking, as an efficient suppressor of EMT and metastasis in breast cancer. AnxA...
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ژورنال
عنوان ژورنال: World Journal of Gastroenterology
سال: 2010
ISSN: 1007-9327
DOI: 10.3748/wjg.v16.i37.4670